Estimation of Release of VEGF From Concentrated Growth Factor compared with that of Platelet Rich Fibrin at Different Time Intervals
Keywords:
Platelet, autologous, regeneration, growth factor.Abstract
Introduction
Autologous platelet concentrate (APC) emerged as innovative autologous blood products that enhance tissue healing and regeneration in regenerative therapy.There are two generations of APC. 1) First Generation: Platelet Rich plasma (PRP) and Plasma rich growth factor (PRGF). 2) Second Generation: Platelet Rich Fibrin (PRF) and Concentrated Growth Factor ( CGF)
Aim
To compare the release of VEGF from CGF with that of PRF at different time intervals of 1, 4 and 7 days
Materials and methods
CGF and PRF have been prepared from human blood. The blood samples were used to quantify the release of VEGF at different time intervals using ELISA kit specific to VEGF. The results were viewed using a spectrophotometer
Results
CGF showed better release of VEGF compared to PRF at 1, 4 and 7 days
Conclusion
CGF can be used as scaffold in Regenerative endodontic therapy.
