A Study on Antidiabetic Potential of Dried Fruits Extract of Eucalyptus Globulus in Experimental Animals

Abstract

The study investigated the antidiabetic potential of an ethanolic fruit extract of Eucalyptus globulus (EG) using male Albino Wistar rats. Diabetes was induced in the rats using Alloxan, and EG was administered orally at different doses (100, 200, and 400mg/kg/day). Glibenclamide was used as a standard drug for comparison. The rats' blood glucose levels and body weight were measured at the beginning and end of the 14-day treatment period. The study also evaluated hypoglycemic effects, oral glucose tolerance, and biochemical parameters associated with diabetes. Histopathological examination of the pancreas was performed to assess any regenerative effects. The results showed that the oral administration of EG significantly reduced blood glucose levels, demonstrated hypoglycemic potential, improved oral glucose tolerance, and increased body weight compared to the toxic control group. Biochemical parameters associated with diabetes also improved with EG treatment. Additionally, histopathological examination revealed that the ethanolic extract of EG helped in the regeneration of pancreatic tissue previously damaged by Alloxan. The findings suggest that the ethanolic fruit extract of EG, which contains bioactive polyphenols like Ellagitannins, has promising antidiabetic properties and merits further investigation in clinical studies and potential drug development.